Abstract
A MeOH extract from Z. africana was examined for topical antiinflammatory activity and proved to be active against arachidonic acid (AA) acute edema, 12-O-tetradecanoylphorbol 13-acetate (TPA)-induced chronic inflammation, and oxazolone delayed-type hypersensitivity in mice. The extract also showed significant inhibitory activity of Naja naja phospholipase A2 when a polarographic method was used. Two oleanane-type triterpene saponins, zanhasaponins A (1) and B (2), and the cyclitol pinitol (4), isolated from the extract, were active as inhibitors of PLA2. A further saponin, zanhasaponin C (3) was inactive in this assay.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adjuvants, Immunologic
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Animals
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology
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Dermatitis, Contact / drug therapy
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Dermatitis, Contact / pathology
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Edema / chemically induced
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Edema / drug therapy
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Edema / pathology
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Enzyme Inhibitors / isolation & purification*
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Enzyme Inhibitors / pharmacology
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Female
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Mice
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Oxazolone
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Peroxidase / antagonists & inhibitors
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Phospholipases A / antagonists & inhibitors*
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Phospholipases A2
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Saponins / isolation & purification*
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Saponins / pharmacology
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Skin / pathology
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Tetradecanoylphorbol Acetate
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Triterpenes / isolation & purification*
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Triterpenes / pharmacology
Substances
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Adjuvants, Immunologic
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Anti-Inflammatory Agents
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Enzyme Inhibitors
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Saponins
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Triterpenes
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zanhasaponin A
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zanhasaponin B
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Oxazolone
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Peroxidase
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Phospholipases A
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Phospholipases A2
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Tetradecanoylphorbol Acetate